Recent Changes

cleft pits alone
missing teeth
of these features.symtoms. It is
{Van_Der.2.jpg} {Van_Der.1.jpg}
Lip mounds (top) and lip pits (bottom) in patients with VWS
What causes VWS?
the basic unitcell of heredity, on chromosomes. Humanspeople have 46
{Van_Der.3.gif}
Can future children have VWS?

Van der Woude Syndrome
By:Michael Allison
What is Van der Woude Syndrome (VWS)?
Clefts of the lip has many causes.
inherited disorder.
Inherited
Inherited disorders are through genes.
About three percent of people with a cleft have VWS. Side effects of VWS include:
mounds or pits on the lower lip
{Van_Der.3.gif}
Can future children have VWS?
dominant gene.
This
This means the the syndrome.
People
People with Disease the child.
They
They also have their children.
Children
Children who inherit a family.
It is not known why some people have lip pits only, some people have lip pits and a cleft, some people have only a cleft, while others do not show any features.
{Van_Der.4.gif}
or both.
It
It is the cleft palate.
The degree to which individuals who carry the gene are affected widely varies, even within families.
varying severity.
Hypodontia (absent teeth) has been increasingly recognized as a frequently associated anomaly.
Others have severe clefting in the lip or palate. Lip pits are often associated with accessory salivary glands that empty into the pits, which occasionally leads to embarrassing visible discharge.

Van der Woude Syndrome
By:Michael Allison
What is Van der Woude Syndrome (VWS)?
Clefts of the lip has many causes.
*
One cause is Van der Woude Syndrome (VWS), an inherited disorder.
*
Inherited disorders are passed from adult to child through genes.
About three percent of people with a cleft have VWS. Side effects of VWS include:
{Van_Der.3.gif}
Can future children have VWS?
dominant gene. This
This means the the syndrome. People
People with Disease the child. They
They also have their children. Children
Children who inherit a family. It
It is not
{Van_Der.4.gif}
or both. It
It is the cleft palate. The
The degree to within families. These
These variable manifestations varying severity. Hypodontia
Hypodontia (absent teeth) associated anomaly. Others
Others have severe visible discharge.
Hypodontia
Hypodontia is present frequently goneh.
History
ClinicalHistoryBecause of its variability, obtaining a detailed family history is important in diagnosing van der Woude syndrome. However, approximately 30-50% of all cases of van der Woude syndrome arise as a de novo mutation.
Physical examination of relatives, close examination of family photos, or interviews of older relatives may be necessary to identify minimally affected family members.
Work Cited
http://emedicine.medscape.com/article/950823-overview
http://www.nidcr.nih.gov/Research/ResearchResults/InterviewsOHR/TIS102002.htm
http://ghr.nlm.nih.gov/condition=vanderwoudesyndrome

http://emedicine.medscape.com/article/950823-overview
http://emedicine.medscape.com/article/950823-overview
http://www.nidcr.nih.gov/Research/ResearchResults/InterviewsOHR/TIS102002.htm
http://ghr.nlm.nih.gov/condition=vanderwoudesyndrome
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Websites
http://craniofacialcenter.uiowa.edu/center/vws.php
http://emedicine.medscape.com/article/950823-overview
http://emedicine.medscape.com/article/950823-overview
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Websites
http://craniofacialcenter.uiowa.edu/center/vws.php
http://emedicine.medscape.com/article/950823-overview
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The pedigree should suggest an autosomal dominant inheritance pattern, unless the phenotype is the result of a de novo mutation in the affected individual. Expressivity also widely varies, and careful clinical examination of parents and relatives may be necessary.
Physical examination of relatives, close examination of family photos, or interviews of older relatives may be necessary to identify minimally affected family members.
http://craniofacialcenter.uiowa.edu/center/vws.phpWork Cited
http://emedicine.medscape.com/article/950823-overview
http://www.nidcr.nih.gov/Research/ResearchResults/InterviewsOHR/TIS102002.htm
http://ghr.nlm.nih.gov/condition=vanderwoudesyndrome

Websites
http://craniofacialcenter.uiowa.edu/center/vws.php
Home

Websites
http://craniofacialcenter.uiowa.edu/center/vws.php

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